Updated Biogas* Research in Japan
Hideo Ueda 1), Ms. Sc.&Tec., Takaharu Kondo 2), M.D., Ph.D., Akiharu Watanabe 3), M.D., Ph.D. and Kyoichi Kobashi 4), Ph.D.

1) Secretariat of Japanese Society of Clinical Biochemistry and Biogas Analyses (JSCBBA)
Director, Mitleben R&D, Inc. A Division of TAIYO Instruments, Inc. Osaka
h-ueda@mitleben.com
2) The 3rd Chairman of JSCBBA (2004~ ) Professor, Human Nutrition, Research Center of Health Physical Fitness and Sports, Nagoya University, Nagoya
3) The 2nd Chairman of JSCBBA (2001~2004). Professor, Kawasaki University of Medical Welfare, Kurashiki., Professor Emeritus (Internal Medicine), Toyama Medical and Pharmaceutical University, Toyama
4) The 1st Chairman of JSCBBA (1998~2001). Professor Emeritus (Biochemistry), Toyama Medical and Pharmaceutical University, Toyama

* Biogas is a new term, which involves breath, flatus (intestinal), oral and other gas generated and contained, especially, in human life activity.

Outlined Activity of JSCBBA

1. Mission
   The purposes of Japanese Society of Clinical Biochemistry and Biogas Analyses (herein after JSCBBA) are to clarify the clinical and patho-physiological significance for every gas component in breath, or biogas and the realization of every biogas-analyzer, which measures one or plural components, for the clinical practice as a non-invasive test manner.

2. History
   1) Origin and the present
   In 1996, researchers belonging to medical doctor, biochemist, and gas analyzer developer who were interesting in breath analysis and application to medical purposes, established “Society of Breath Analysis and Application” and Meeting was held every 6 months during 2 years. Breath researches for acetone, isoprene, hydrogen and methane, and ammonia analyzer had been performed. And at the establishment of JSCBBA, the book titled “Biogas -Analysis and Significance”(Japanese language) was published, and held the 1st Scientific Meeting in 1998, and thereafter the Meeting has been held annually.
   In 2004, 7th JSCBBA meeting was firstly joined to Japanese Society of 13C medical application, which was developed as a fruit and applied in clinical practice in the detection of urease activity of H.pylori infected in stomach.

   2) Previous Annual Meetings
   This year 8th Meeting 2005 will be held in Tokyo under the organizer of Prof. Kondo, M.D., Ph.D. Followings are the yearly organizers from the 1st Meeting 1998.

1st Meeting 1998 in Tokyo, organized by Prof. Kyoichi Kobashi, Ph.D.
2nd Meeting 1999 in Toyama, organized by Prof. Akiharu Watanabe, M.D., Ph.D.
3rd Meeting 2000 in Osaka, organized by Yutaka Harano, M.D., PH.D. Director of Atherosclerosis metabolism and Clinical nutrition, National cardiovascular center, Osaka
4th Meeting 2001 in Tokyo, organized Masayuki Totani, M.D., D.M.Sc. Director of Maternal and Child Health Science, The National Institute of Health and Nutrition, Tokyo
5th Meeting 2002 in Osaka, organized by Toshio Umemoto, D.D.S., Ph.D. Professor, Oral Bacteriology, Kanagawa Dental College, Yokosuka
6th Meeting 2003 in Tokyo, organized by Yoshimi Benno, D.V.M., Ph.D. Director of Japan Collection of Microorganisms, Riken, Wako
7th Meeting 2004 in Sakura,Chiba, organized by Teruo Nakamura, M.D., Ph.D. Professor, Hirosaki University School of Medicine, Hirosaki
3. Fruits obtained from activity
   1) Publications (Japanese language)
@ Biogas ?Analysis & Significance (1998, Osaka)
A Proceedings on Biogas Research (1), 1999
B Proceedings on Biogas Research (2), 2000
C Proceedings on Biogas Research (3), 2003
D Proceedings on Biogas Research (7), 2005

       2) Analyzers Developed
        Analyzers developed after the establishment of JSCBBA are as follows. These were developed as an exclusive analyzer, respectively for clinical test instrument with a compact design, simple operation and rapid result.
@ Oral Ammonia Analyzer (Ammonia formed with anaerobic (urease-formed) bacteria and urea, Mitleben, Osaka, 1998)
A Breath 13CO2 Analyzer (for H.pylori Infection in Stomach, Otsuka, Osaka, 1998)
B Breath Hydrogen & Methane Analyzer (Teramex, Kyoto, 1999)
C Breath Isoprene Analyzer (Mitleben, Osaka, 2000)
D Breath CO/CO2 Analyzer (Mitleben/TAIYO, Osaka, 2001)
E Biogas (CO/H2/CH4) Analyzer (Mitleben/TAIYO, Osaka, 2003)
F Oral VSC (H2S/CH3SH/(CH3)2S) Analyzer for Halitosis (FIS/Abilit, Osaka, 2003)
G Breath Acetone Analyzer (FIS, Itami, 2003)
H Flatus Gas Monitor (Mitleben/Adonis, Osaka, 2004)
I Ambient VOCs Analyzer (FIS, Itami, 2004)

4. Present and near future
    During almost ten years passed, we have developed many effective technologies for the clinical test instrument, which are indispensable for a compact size and simple operation as a bed-side test, and analyzers described above are now in clinical field to accumulate the data for clarifying clinical significance of the gas, respectively. Biogas including breath, oral, cutaneous and flatus gas analysis is an effective non-invasive technique for clinical test, therefore those analyzers will be expected to be realized in practical use in the coming near future.

2005/05/22 ML